Medications containing St. John's wort have been observed to interact with the following medicines, reducing their effects:
- oral anticoagulants (blood thinning medicines) of the coumarin type (warfarin and phenprocoumon)
- drugs that suppress transplant rejection reactions: such as cyclosporin, tacrolimus for internal use, sirolimus
- digoxin (drug for heart failure)
- drugs for the treatment of HIV infections and AIDS
- protease inhibitors such as indinavir
- non-nucleoside reverse transcriptase inhibitors such as nevirapine
- cytotoxic drugs such as imitanib, irinotecan, except for monoclonal antibodies
- verapamil (drug for the treatment of heart rhythm disorders, coronary heart disease, high blood pressure, cluster headaches, heart muscle disease)
- cholesterol-lowering drugs of the statin type, such as simvastatin
- triptans (migraine therapies)
- antiepileptic drugs
- various drugs for depression, such as amitriptyline, nortriptyline, midazolam. Patients taking this medicine together with antidepressants, which inhibit serotonin re-uptake (such as paroxetine, sertraline, trazodone), may experience more pronounced serotonergic effects (such as nausea, vomiting, anxiety, restlessness, confusion)
Patients taking NEURAPAS® balance together with any medication that contains any of the above mentioined drugs should ask their doctor for advice.
Women taking hormonal birth control pills may experience intermenstrual bleeding. Also, patients are recommended to use additional non-hormonal methods of birth control while taking NEURAPAS® balance.
Patients taking this medicine together with other medications that increase the skin's sensitivity to light may experience increased injury from light exposure (see 'Possible side effects').